Abstract: Pre-splitting blasting is often used in slope engineering construction, pre-splitting parameters have important effects on reducing blasting vibrations. Pre-splitting blasting experiments were carried out to obtain normal pre-splitting blasting parameters such as hole diameter, hole space, gunpowder charge line density, and uncoupling factor. Ideal pre-splitting blasting parameters for four different hole diameters gained by the code ANSYS/LS-DYNA agree with the blasting experiments. By regression analysis, a simple fomula was given to choose the pre-splitting blasting parameters and to guide the succedent construction. Practice shows that combination of blasting experiments and numerical simulations is helpful to optimize pre-splitting blasting parameters.