Abstract: The complex problem on damage experienced by missile projects impacted by blast wave was simplified to explore the damage mechanism of the missile structures. Mechanical damage of missile projects was estimated with the dynamics knowledge. A numerical code was developed by taking charge mass of the warhead, the distance between the explosion point and the missile, the surrounding pressure at the explosion altitude, the geometry size of the missile, and the performance of the missile against shock loading into account. A series of numerical calculations were carried out by the newly-developed program code to investigate the damage of the missile by blast wave, which was produced by the warhead in cases of different times, different locations, and different charge masses. The computational results are basically in accord with the theory. This can explain that the adopted model and calculation method are reasonable and they can be used to evaluate the vulnerability of missile projects under blast overpressure.