Abstract: The common node separate reinforced concrete model was adopted to numerically simulate the fold blasting collapse processes of frame-tube structures. The two blasting methods used in the three-dimensional simulations included the bottom blasting and the top blasting. In the bottom blasting methods, different cut height and delay time were considered. The collapse processes of the frame-tube structures and the failure processes of the sustaining pillars were discussed. The bottom of the structure was crushed more seriously by using the bottom blasting method than that by using the top blasting method. For the bottom blasting method, more fragmentation appeared in the structure with the 0.25 s delay time than that with 0.5 s. The structure collapsed southward appreciably with the different cut heights and delay times. The failure processes of the sustaining pillars were different according to the different blasting methods, which influenced the backlash distance of the structure. The backlash distance of the structure under the bottom blasting was smaller than that under the top blasting. Stress analysis of the concrete and reinforcement elements shows that the common node separate reinforced concrete model can reflect the mechanical property differences between the two materials.