Abstract: Ultra High Performance Concrete (UHPC) is a new type of protective material with both ultra-high strength and ultra-high toughness can be adopted as an ideal material in the impact resistant design of structures. In this paper, the impact resistance of 160MPa UHPC was investigated experimentally by conducting the high-speed projectile penetration tests which launched by the 30mm-diameter, smooth-bore powder gun at the striking velocities 216 m/s and 350 m/s. The test results show that with the increase of projectile velocity, the penetration depth and crater diameter increase obviously. The MAT_RHT is implemented into finite element package LS-DYNA for UHPC. In order to verify the accuracy of the material model, split Hopkinson pressure bar (SHPB) testing results are used to validate 3D finite element material model. With the validated numerical model of UHPC, Numerical studies are conducted to simulate the projectile penetration process into UHPC targets with the assistance of a computer program LS-DYNA. The numerical results in terms of the depth of penetration and crater diameter are compared with the experimental results. In addition, parametric studies are conducted to investigate effects of UHPC compressive strength, projectile mass, projectile striking velocity, projectile diameter and projectile caliber-radius-head (CRH) ratio on the depth of penetration of UHPC targets. Moreover, an empirical formula to predict the depth of penetration is derived according to the simulated data.