Abstract: Fluoropolymer-based reactive materials serve as new damage materials with high destructive efficient, capable of structural damage to targets through a combination of terminal kinetic energy penetration and internal energy release effects under strong dynamic loads during high-speed impact. However, due to the limitations of low material density and strength, the application scope of fluoropolymer-based reactive materials is difficult to widely promote and is limited. A novel reactive fragment with core-shell structure was proposed, with the same relative density as PTFE/Al/CF/W reactive fragments. Through equivalence analysis of typical military targets with high value, multi-layered targets were determined as damage targets for reactive fragments penetration and damage effectiveness. Three-dimensional scanning of the target plates was performed after testing. Several self-developed programs were used for automatic data processing to extract characteristics such as perforation area, deformation volume of the target plate, and the light emissions. These were then used as criteria for damage assessment to compare and analyze the damage effectiveness of different structural reactive fragments under different constraints. The research results have certain reference value for the structural design and effect evaluation of active fragments.