Abstract: Zr-based amorphous alloy has excellent mechanical properties such as high strength and high hardness. It has important application value as a warhead fragment damage element. To investigate the dispersion characteristics and deformation behavior of Zr-based amorphous alloy fragments driven by detonation of a circumferentially focusing charge, the static explosion tests of Zr-based amorphous alloy fragments driven by cylinder and trumpet-shaped circumferentially focusing warheads were carried out, and the spatial distribution characteristics of fragments under two charge structures were obtained. Using the fragment recovery device, the detonation-driven Zr-based amorphous alloy fragments were recovered. Combined with numerical simulations, the influence of the charge generatrix shape on the dispersion behavior of the fragments was analyzed, and the effect of the flameproof layer thickness on the fragmentation behavior of the fragments was investigated. The results show that, compared with the cylinder charge structure, the trumpet-shaped circumferentially focusing charge significantly reduces the fragment scattering angle. When the focusing radius of curvature is 600 mm, the width of the focusing band containing 70% of the fragments is reduced of 38.4%. Moreover, at the flameproof layer thickness of 8 mm, slight fragmentation occurs, but the main-body fragments can penetrate and damage a 3 mm thick Q235 steel target. Within a certain range, reducing the curvature radius of the focusing generatrix facilitates fragment convergence; However, if the radius is too small, it will cause excessive squeezing and fragmentation of the fragments. Appropriately reducing the diameter of the upper end of the charge can not only shift the focusing band toward the central area of the target, but also improve the uniformity of fragment distribution within the focusing band. Because Zr-based amorphous alloy fragments are prone to fragmentation under detonation loading, the degree of fragmentation can be controlled by adjusting the thickness of the flameproof layer. The optimal flameproof layer thickness for achieving relatively intact driving of Zr-based amorphous alloy fragments is 8 mm. If the thickness is less than this value, the fragments will be severely fragmented; If the thickness is greater than this value, velocity loss will increase. The research results in this paper provide data and technical support for the engineering application of Zr-based amorphous alloy materials in blast-fragmentation warheads.